Nociceptor-immune interactomes reveal insult-specific immune signatures of pain.
Jain, A. et.al., Nature Immunology
Immune drivers of pain resolution and protection.
Hakim, S.*, Jain, A. *& Woolf, C.J. I, Nature Immunology
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.
Jain, A. et. al., Nature Immunology
Key Publications
2025
Macrophages protect against sensory axon loss in peripheral neuropathy. Hakim, S., Jain, A., Adamson, S.S. et al., Nature
2024
Immune drivers of pain resolution and protection. Hakim, S.*, Jain, A. & Woolf, C.J. I, Nature Immunology. * Equal contribution
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Philipp Starkl et al., Science Immunology
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia. Shamsuddin A. Bhuiyan et al., Science Advances
Immune drivers of physiological and pathological pain. Jain. A.*, Hakim. A.*, Woolf, C.J., J Exp Med. *Equal contribution
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain. Jain, A. et.al., Nature Immunology
2022
Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. McDaniel, M.M.*, Chawla, A.S.*, Jain, A.*, et. al., Science Immunology. *Equal contribution
2019
2018
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells. Jain, A. et. al., Nature Communications